BiologicalActivity
Potentandselectiveinhibitorofintegrinsαvβ3andαvβ5(IC50valuesare4.1and70nM,respectively).Exhibits~10-foldselectivityovergpIIb/IIIa.IncreasesendothelialmonolayerpermeABIlity.Alsoexhibitsantiangiogenicactivity.
TechnicalData
| M.Wt | 588.66 |
| Formula | C27H40N8O7 |
| Sequence | RGDFV (Modifications:Phe-4=D-Phe,Val-5=Me-Val,Cyclizedl) |
| Storage | Storeat-20°C |
| CASNumber | 188968-51-6 |
| PubChemID | 176873 |
| InChIKey | AMLYAMJWYAIXIA-VWNVYAMZSA-N |
| Smiles | CC(C)[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto10mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight588.66.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.7mL | 8.49mL | 16.99mL |
| 5mM | 0.34mL | 1.7mL | 3.4mL |
| 10mM | 0.17mL | 0.85mL | 1.7mL |
| 50mM | 0.03mL | 0.17mL | 0.34mL |
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