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Description:Tubulinpolymerizationinhibitor.Antitumorinvivo
ChemicalName:(5-Methoxy-1H-indol-2-yl)phenylmethanone
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Novelinhibitoroftubulinpolymerization;cytotoxicandinhibitstumorcellproliferationinvitro(IC50=74nM).PreventsgrowthoftumormodelsinmicefollowingoraladmiNISTrationinvivo.
TechnicalData
M.Wt | 251.28 |
Formula | C16H13NO2 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 74588-78-6 |
PubChemID | 3921152 |
InChIKey | ICMIJSRDISNKOC-UHFFFAOYSA-N |
Smiles | COC1=CC=C2NC(=CC2=C1)C(=O)C1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 25.13 | 100 | |
ethanol | 5.03 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight251.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.98mL | 19.9mL | 39.8mL |
5mM | 0.8mL | 3.98mL | 7.96mL |
10mM | 0.4mL | 1.99mL | 3.98mL |
50mM | 0.08mL | 0.4mL | 0.8mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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