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Tocris/Dolastatin 10 trifluoroacetate/3375/1/1 mg

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Tocris/Dolastatin 10 trifluoroacetate/3375/1/1 mg

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Tocris

货号 /

3375/1

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4000-520-616

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Description:Tubulinpolymerizationinhibitor

ChemicalName:N,N-Dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazol)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl--valinamidetrifluoroacetate

Purity:≥95%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Tubulinpolymerizationinhibitor.NoncompetitivelyinhibitsbindingofrADIolabeledvincristinetotubulin(K_i=1.4μM)andinducestubulinaggregationinvitro.

TechnicalData

M.Wt	899.11
Formula	C₄₂H₆₈N₆O₆S.CF₃CO₂H
Storage	Storeat-20°C
Purity	≥95%(HPLC)
PubChemID	9810929
InChIKey	OFDNQWIFNXBECV-VFSYNPLYSA-N
Smiles	O=C(C[C@@H](OC)[C@@H](N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)[C@@H](C)CC)N1[C@@]([C@H](OC)[C@@H](C)C(N[C@@H](CC3=CC=CC=C3)C2=NC=CS2)=O)([H])CCC1.FC(C(O)=O)(F)F

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

Solubility	SolubleinDMSO

Solubility

SolubleinDMSO

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight899.11.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.11mL	5.56mL	11.12mL
5mM	0.22mL	1.11mL	2.22mL
10mM	0.11mL	0.56mL	1.11mL
50mM	0.02mL	0.11mL	0.22mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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