BiologicalActivity
HighaffinityfluorescentlytaggedaptamerforEpCam(Kd=39.42nMinHT29cells).EfficientlyinternalizeduponbindingtoEpCAM.Exhibitsrapidpenetrationoftumorspheresinvitro,aswellassuperiorpenetration,accumulationandretentionintumorxenograftsinvivothananantibodytothesametarget.
Foroptimalbindingaptamersrequirerefoldingintotheirtertiarystructurepriortouse.Pleaserefertotheaccompanyingrefoldingprotocol.
LicensingInformation
Soldunderlicensefromthepatentholder,DeakinUniversity
TechnicalData
| M.Wt | 6782.21 |
| Formula | C218H259F13N66O132P20 |
| Storage | Storeat-20°C |
| Aptamertype(DNA/RNA) | RNA |
| NumberofBases | 19 |
| SequenceModifications | 2-fluoropyrimidines,3'-inverteddeoxythymidinecap,5'-fluorescentDY647tag |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility
PleaserefertothesesolubilityguidelinesforEp23,5'-DY647(Cat.No.6102).
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight6782.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.15mL | 0.74mL | 1.47mL |
| 5mM | 0.03mL | 0.15mL | 0.29mL |
| 10mM | 0.01mL | 0.07mL | 0.15mL |
| 50mM | 0mL | 0.01mL | 0.03mL |
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