Tocris型号参数规格 Tocris Bioscience美元价/进货价,Tocris/Epothilone B/3502/100U/100 ug,其他试剂,其他,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/Epothilone B/3502/100U/100 ug

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Tocris

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3502/100U

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4000-520-616

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Description:MicrotubulestABIlizationagent;promotestubulinpolymerization

AlternativeNames:Patupilone

ChemicalName:(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

MicrotubulestabilizationagentthatpromotestubulinpolymerizationandinducesG₂-Mcellcyclearrest(EC₅₀=32nMinHeLacells).Inhibitsproliferationofhumancarcinomacelllinesinvitro,includingMDRcellsoverexpressingtheP-glycoproteineffluxpump.ExhibitspotentcytotoxicityinMCF-7andA549cells(EC₅₀valuesare0.3and2.7nMrespectively).InhibitsgrowthofHCT-15tumorsinmiceinvivo.

TechnicalData

M.Wt	507.68
Formula	C₂₇H₄₁NO₆S
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	152044-54-7
PubChemID	448013
InChIKey	QXRSDHAAWVKZLJ-PVYNADRNSA-N
Smiles	CC1=NC(/C=[C@](C)/[C@@H](OC2=O)C[C@H]3[C@@](O3)(C)CCC[C@H](C)[C@H](O)[C@H](C([C@@](C)(C)[C@@H](O)C2)=O)C)=CS1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	5.08	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight507.68.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.97mL	9.85mL	19.7mL
5mM	0.39mL	1.97mL	3.94mL
10mM	0.2mL	0.98mL	1.97mL
50mM	0.04mL	0.2mL	0.39mL

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BiologicalActivity

TechnicalData

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