BiologicalActivity
Naturallyoccuringflavonoidandantioxidant.InhibitsPI3-K,Akt,mTORandCdk6.Displaysantiproliferativeactivityinprostatecancercells.ShowntoactivateERK;exhibitsneuroprotectiveactivityinHuntington'sdiseasemodels.AlsoaDNMT1inhibitor.
CompoundLibraries
FisetinisalsoofferedaspartoftheTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 286.24 |
| Formula | C15H10O6 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 528-48-3 |
| PubChemID | 5281614 |
| InChIKey | XHEFDIBZLJXQHF-UHFFFAOYSA-N |
| Smiles | OC2=C(C3=CC=C(O)C(O)=C3)OC1=CC(O)=CC=C1C2=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.62 | 100 | |
| ethanol | 2.86 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight286.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.49mL | 17.47mL | 34.94mL |
| 5mM | 0.7mL | 3.49mL | 6.99mL |
| 10mM | 0.35mL | 1.75mL | 3.49mL |
| 50mM | 0.07mL | 0.35mL | 0.7mL |
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