BiologicalActivity
Microtubuledestabilizerthatblockstubulinpolymerization(IC50=0.3μM).Blockscellcycleprogressionatmetaphaseanddisplaysantitumoractivityagainstavarietyofmalignanciesinvitro(IC50valuesrangingfrom0.036-0.285μM).InducescompletetumorremissionintheYoshidaAH13ratsarcomamodelinvivo.Lacksneurotoxicityduetoanabilitytodiscriminatebetweenposttranslationallymodifiedtubulininmatureneuronalmicrotubulesandless-modifiedtubulinpresentinimmatureneuronalornonneuronalmicrotubules.DisplaysoralavailabilityandefficacytowardsMDRtumorcells.
TechnicalData
| M.Wt | 389.83 |
| Formula | C22H16ClN3O2 |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 204205-90-3 |
| PubChemID | 2929 |
| InChIKey | SOLIIYNRSAWTSQ-UHFFFAOYSA-N |
| Smiles | ClC(C=C3)=CC=C3CN2C1=CC=CC=C1C(C(C(NC4=CC=NC=C4)=O)=O)=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.75 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight389.83.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.57mL | 12.83mL | 25.65mL |
| 5mM | 0.51mL | 2.57mL | 5.13mL |
| 10mM | 0.26mL | 1.28mL | 2.57mL |
| 50mM | 0.05mL | 0.26mL | 0.51mL |
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