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Description:PhotoswitchableKvchannelblocker
ChemicalName:N,N,N-Triethyl-2-oxo-2-[[4-[2-[4-[(1-oxo-2-propen-1-yl)amino]phenyl]diazenyl]phenylamino]ethanaminiumchloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PhotoswitchableKvchannelblocker(IC50valuesare2and64μMat500nmand380nmrespectively).Switchesconformationfromcistotransat500nmandtranstocisat380nm.ExhibitsminimalactivityatNav1.2andL-typeCa2+channels.Stimulatesactionpotentialfiringofhippocampalneuronsinvitroat500nmandrestoresvisualresponsivenessinblindmiceat380nm.
LicensingInformation
SoldunderlicensefromPhotoswitchBiosciences,Inc.
TechnicalData
M.Wt | 443.97 |
Formula | C23H30ClN5O2 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
PubChemID | 91826090 |
InChIKey | CTVKLIGDHHKPIB-UHFFFAOYSA-N |
Smiles | O=C(C=C)NC(C=C2)=CC=C2/N=N/C1=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C1.[Cl-] |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 8.88 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight443.97.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.25mL | 11.26mL | 22.52mL |
5mM | 0.45mL | 2.25mL | 4.5mL |
10mM | 0.23mL | 1.13mL | 2.25mL |
50mM | 0.05mL | 0.23mL | 0.45mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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