BiologicalActivity
AllostericactivatorofCD11b/CD18.IncreasesCD11b/CD18-dependentcelladhesiontofibrinogen(EC50=4μM).Decreasesleukocytemotilityandtransendothelialmigration;reducesinflammation.Alsoactivatescomplementreceptor3(CR3),andpromotesCR3-dependentleukocyteadhesiontofibrinogen-coatedsurfaces.
TechnicalData
| M.Wt | 421.49 |
| Formula | C22H15NO4S2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 344897-95-6 |
| PubChemID | 5342077 |
| InChIKey | AEZGRQSLKVNPCI-UNOMPAQXSA-N |
| Smiles | S=C(N(CC3=CC=CC=C3)C2=O)S/C2=CC1=CC=C(C4=CC=C(C(O)=O)C=C4)O1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.21 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight421.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.37mL | 11.86mL | 23.73mL |
| 5mM | 0.47mL | 2.37mL | 4.75mL |
| 10mM | 0.24mL | 1.19mL | 2.37mL |
| 50mM | 0.05mL | 0.24mL | 0.47mL |
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