Tocris代理，产品目录 Tocris离子通道调控剂,Tocris/MMAE/5683/1/1 mg,其他试剂,其他,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/MMAE/5683/1/1 mg

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Tocris

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5683/1

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Description:Potentdolastatin10analog;antitumor

ChemicalName:N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent,synthetic,cytotoxicanalogofdolastatin10(Cat.No.3375).SuppressestumorcellviABIlityinvitro(GIC₅₀valuesare0.22,0.49and0.54nMinBT474,MDA-MB-361-DYT2andN87cells,respectively).MMAEderivativeshavebeenshowntoinduceregressionofestablishedtumorxenograftswhenconjugatedtotumortargetingantibodiesviaaprotease-cleavablelinker.

TechnicalData

M.Wt	717.98
Formula	C₃₉H₆₇N₅O₇
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	474645-27-7
PubChemID	11542188
InChIKey	DASWEROEPLKSEI-UIJRFTGLSA-N
Smiles	O=C(C[C@@H](OC)[C@@H](N(C)[C@@]([C@H](C(C)C)NC([C@H](C(C)C)NC)=O)=O)[C@@H](C)CC)N1[C@@]([C@@H]([C@H](C(N[C@@H]([C@@H](O)[C@]2=CC=CC=C2)C)=O)C)OC)([H])CCC1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	71.8	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight717.98.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.39mL	6.96mL	13.93mL
5mM	0.28mL	1.39mL	2.79mL
10mM	0.14mL	0.7mL	1.39mL
50mM	0.03mL	0.14mL	0.28mL

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