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Description:GPR171antagoNIST
ChemicalName:N-Methyl-5-[(phenylmethyl)thio]-1,3,4-thiazADIazol-2-amine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
GPR171antagonist(IC50=220nM).InhibitsBigLEN(Cat.No.6304)mediatedincreasesin[35S]GTPγSbindinginhypothalamicmembranesandhyperpolarizationofbasolateralamygdalapyramidalneurons.Reducesanxiety-likebehaviorandfearconditioninginmice.
TechnicalData
M.Wt | 237.34 |
Formula | C10H11N3S2 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 65373-29-7 |
PubChemID | 805117 |
InChIKey | KFLNRVSOQJTXDG-UHFFFAOYSA-N |
Smiles | CNC1=NN=C(S1)SCC2=CC=CC=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 23.73 | 100 | |
ethanol | 23.73 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight237.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.21mL | 21.07mL | 42.13mL |
5mM | 0.84mL | 4.21mL | 8.43mL |
10mM | 0.42mL | 2.11mL | 4.21mL |
50mM | 0.08mL | 0.42mL | 0.84mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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