生命科学Tocris价格优惠 TOCRIS 4372-10MG,Tocris/Maritoclax/5368/10/10 mg,其他试剂,其他,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/Maritoclax/5368/10/10 mg

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Tocris

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5368/10

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4000-520-616

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Description:Mcl-1inhibitor;proapoptotic

ChemicalName:1,1'-(4,4',5,5'-Tetrachloro[1,3'-bi-1H-pyrrole]-2,2'-diyl)bis[1-2-hydroxyphenyl)methanone

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Mcl-1inhibitor;disruptsMcl-1-BiminteractionandinducesMcl-1proteasomaldegradation.ExhibitsnoeffectonBcl-X_L-Biminteraction.SelectivelyinducesapoptosisinMcl-1-dependentK562leukemiacells.SensitizesK562andRajicellstoABT-737-inducedapoptosis.

TechnicalData

M.Wt	510.15
Formula	C₂₂H₁₂Cl₄N₂O₄
Storage	Storeat-20°C
Purity	≥97%(HPLC)
CASNumber	1227962-62-0
PubChemID	24797083
InChIKey	QYPJBTMRYKRTFG-UHFFFAOYSA-N
Smiles	ClC1=C(Cl)C(N2C(C(C4=C(O)C=CC=C4)=O)=CC(Cl)=C2Cl)=C(C(C3=C(O)C=CC=C3)=O)N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	51.01	100
	ethanol	25.51	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight510.15.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.96mL	9.8mL	19.6mL
5mM	0.39mL	1.96mL	3.92mL
10mM	0.2mL	0.98mL	1.96mL
50mM	0.04mL	0.2mL	0.39mL

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BiologicalActivity

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