BiologicalActivity
IrreversiblemitochondrialrespiratorycomplexII(succinatedehydrogenase)inhibitor;inducesautophagyinSH-SY5Ycells.RecapitulatesHuntington'sdisease-likepathologyandsymptomsinprimateandrodentmodels.
TechnicalData
| M.Wt | 119.08 |
| Formula | C3H5NO4 |
| Storage | Storeat+4°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 504-88-1 |
| PubChemID | 1678 |
| InChIKey | WBLZUCOIBUDNBV-UHFFFAOYSA-N |
| Smiles | OC(CC[N+]([O-])=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.91 | 100 | |
| ethanol | 11.91 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight119.08.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 8.4mL | 41.99mL | 83.98mL |
| 5mM | 1.68mL | 8.4mL | 16.8mL |
| 10mM | 0.84mL | 4.2mL | 8.4mL |
| 50mM | 0.17mL | 0.84mL | 1.68mL |
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