Tocris批发，产品货源 Tocris Bioscience中国采购,Tocris/Obtustatin/4664/100U/100 ug,其他试剂,其他,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/Obtustatin/4664/100U/100 ug

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Tocris

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4664/100U

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4000-520-616

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Description:Potentandselectiveα₁β₁inhibitor

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Highlypotentintegrinα₁β₁inhibitor(IC₅₀=0.8nMforα₁β₁bindingtotypeIVcollagen).Selectiveforα₁β₁overα₂β₁,α_IIbβ₃,α_vβ₃,α₄β₁,α₅β₆,α₉β₁andα₄β₇.InhibitsFGF2-stimulatedangiogenesisinthechickenchorioallantoicmodel.DisplaysantitumorefficacyinasynergisticmousemodelofLewislungcarcinoma;blockshumanmelanomagrowthinnudemice.

TechnicalData

M.Wt	4393.07
Formula	C₁₈₄H₂₈₄N₅₂O₅₇S₈
Sequence	CTTGPCCRQCKLKPAGTTCWKTSLTSHYCTGKSCDCPLYPG (Modifications:Disulfidebridge:1-10,6-29,7-34,19-36)
Storage	Storeat-20°C
PubChemID	90488962
InChIKey	XXWNADNJWWLFFP-UHFFFAOYSA-N
Smiles	[H]N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CSSC[C@@H]4NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H]5CCCN5C(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N3)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=CNC3=C1C=CC=C3)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC4=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC2=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

Solubility	Solubleto1mg/mlinwater

Solubility

Solubleto1mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight4393.07.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	0.23mL	1.14mL	2.28mL
5mM	0.05mL	0.23mL	0.46mL
10mM	0.02mL	0.11mL	0.23mL
50mM	0mL	0.02mL	0.05mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

MolarityCalculator

ReconstitutionCalculator

DilutionCalculator

ProductDatasheets