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Description:PotentC5areceptorpeptideantagoNIST
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PotentC5areceptorpeptideantagonist(IC50=31nM).Amelioratesexperimentally-inducedcoloninflammationinmice.Reducesfibrillaramyloiddeposits,decreaseshyperphosphorylatedtaulevelsandrescuescognitivefunctioninamousemodelofAlzheimer'sDisease.Orallyactiveandbrainpenetrant.
TechnicalData
M.Wt | 839.05 |
Formula | C45H62N10O6 |
Sequence | XPXWR (Modifications:X-1=N2-(1-Oxo-3-phenylpropyl)-Orn,X-3=D-Cha,Lactambridge:Orn-1toArg-5) |
Storage | Storeat-20°C |
CASNumber | 514814-49-4 |
PubChemID | 90489023 |
InChIKey | YUIBSMOWXFHTBD-UHFFFAOYSA-N |
Smiles | NC(=N)NCCCC1NC(=O)C(CC2C=NC3=CC=CC=C23)NC(=O)C(CC2CCCCC2)NC(=O)C2CCCN2C(=O)C(CCCNC1=O)NC(=O)CCC1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solubility | Solubleto1mg/mlinwaterwithsonication |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight839.05.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.19mL | 5.96mL | 11.92mL |
5mM | 0.24mL | 1.19mL | 2.38mL |
10mM | 0.12mL | 0.6mL | 1.19mL |
50mM | 0.02mL | 0.12mL | 0.24mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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