BiologicalActivity
SuppressessuperoxideproductionbycomplexIIIinthemitochondriawithoutaffectingnormalelectronfluxorcellularoxidativephosphorylation(IC50=1.7μM).SuppressesHIF-1αaccumulationandenhancessurvivalandfunctionofprimarypancreaticisletsinvitro.Cellpermeable.
TechnicalData
| M.Wt | 323.44 |
| Formula | C19H25N5 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 890888-12-7 |
| PubChemID | 17017624 |
| InChIKey | MGIAJZSCNPODRR-UHFFFAOYSA-N |
| Smiles | CC(C(C)=C1)=CC=C1N2C3=NC=NC(N(CCC)CCC)=C3C=N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.47 | 20mMwithgentlewarming | |
| ethanol | 6.47 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight323.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.09mL | 15.46mL | 30.92mL |
| 5mM | 0.62mL | 3.09mL | 6.18mL |
| 10mM | 0.31mL | 1.55mL | 3.09mL |
| 50mM | 0.06mL | 0.31mL | 0.62mL |
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