Tocris厂家直采，平行进口 Tocris Bioscience一级代理,Tocris/MS 15203/6299/25/25 mg,其他试剂,其他,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/MS 15203/6299/25/25 mg

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Tocris

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6299/25

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4000-520-616

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Description:PotentandselectiveGPR171partialagoNIST

ChemicalName:5-[(2-Methyl-1-oxo-2-propen-1-yl)amino]-1,3-benzenedicarboxylicacid

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveGPR171partialagonist(EC₅₀=90nM;28%inhibitionofforskolinactivatedadenylylcyclaseactivityinrathypothalamicmemebranes).Exhibitsminimalbindingtoapanelof~70GPCRsand10otherreceptors(<22%ofrADIoliganddisplacedfromthetargetreceptors).Increasesneuronalactivityintheparaventricularnucleus.Increasesfoodintakeandbodyweightinmice.

TechnicalData

M.Wt	249.22
Formula	C₁₂H₁₁NO₅
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	73912-52-4
PubChemID	773544
InChIKey	NVOBVSWSDYFEMR-UHFFFAOYSA-N
Smiles	CC(C(NC1=CC(C(O)=O)=CC(C(O)=O)=C1)=O)=C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	24.92	100
	ethanol	4.98	20mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight249.22.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	4.01mL	20.06mL	40.13mL
5mM	0.8mL	4.01mL	8.03mL
10mM	0.4mL	2.01mL	4.01mL
50mM	0.08mL	0.4mL	0.8mL

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