中国Tocris公司 Tocris GPCR ligands,Tocris/TW 37/4038/50/50 mg,其他试剂,其他,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/TW 37/4038/50/50 mg

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Tocris

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4038/50

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Description:Bcl-2inhibitor;inducesapoptosis

ChemicalName:N-[4-[[2-(1,1-Dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]benzamide

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Bcl-2inhibitor(K_ivaluesare0.29μMand1.11μMforBcl-2andBcl-XLrespectively).Inhibitstheangiogenicpotentialofendothelialcellsinvitro.InducesS-phasearrestandapoptosisinpancreaticcancercelllines;alsoinhibitstheactivationofNotch-1andJagged-1invitroandinvivo.

TechnicalData

M.Wt	573.7
Formula	C₃₃H₃₅NO₆S
Storage	Storeat-20°C
Purity	≥97%(HPLC)
CASNumber	877877-35-5
PubChemID	11455910
InChIKey	PQAPVTKIEGUPRN-UHFFFAOYSA-N
Smiles	OC1=C(CC2=C(C(C)C)C=CC=C2)C=C(C(NC3=CC=C(S(C4=C(C(C)(C)C)C=CC=C4)(=O)=O)C=C3)=O)C(O)=C1O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	57.37	100
	ethanol	2.87	5

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight573.7.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.74mL	8.72mL	17.43mL
5mM	0.35mL	1.74mL	3.49mL
10mM	0.17mL	0.87mL	1.74mL
50mM	0.03mL	0.17mL	0.35mL

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