BiologicalActivity
Inhibitorofmicrotubulepolymerizationinvitro.Interactswithtubulindimersandpromotestheaccumulationofmammaliancellsinapoptosis.Potentiatesantiproliferativeeffectsofvinblastine(Cat.No.1256)inH2B-GFPHeLacells.OriginallythoughttoinhibitCENP-EATPaseactivity.
TechnicalData
| M.Wt | 353.37 |
| Formula | C23H15NO3 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 313367-92-9 |
| PubChemID | 3383533 |
| InChIKey | SVICLWPFAQYZLX-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC=CC(C4=NC=C(C5=CC=C(OC)C=C5)O4)=C1C3=C2C=CC=C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.83 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight353.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.83mL | 14.15mL | 28.3mL |
| 5mM | 0.57mL | 2.83mL | 5.66mL |
| 10mM | 0.28mL | 1.41mL | 2.83mL |
| 50mM | 0.06mL | 0.28mL | 0.57mL |
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