BiologicalActivity
PotentinhibitorofL3MBTL3methyllysine(Kme)readerdomain(IC50=40nM;Kd=120nM).Displays>100-foldselectivityoverapanelofhistonemethyltransferases,kinases,ionchannelsand7-TMreceptors.Disruptssubnuclearlocalizationandfociformationoffluorescently-labeledL3MBTL3inHEK293cells.
LicensingInformation
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheUNC1215probesummaryontheSGCwebsite.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofUNC1215isreviewedonthechemicalprobeswebsite.
CompoundLibraries
UNC1215isalsoofferedaspartoftheTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 529.72 |
| Formula | C32H43N5O2 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| PubChemID | 57339144 |
| InChIKey | PQOOIERVZAXHBP-UHFFFAOYSA-N |
| Smiles | O=C(N2CCC(N3CCCC3)CC2)C1=C(NC6=CC=CC=C6)C=C(C(N4CCC(N5CCCC5)CC4)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 2eq.HCl | 52.97 | 100 | |
| DMSO | 26.49 | 50 | |
| ethanol | 52.97 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight529.72.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.89mL | 9.44mL | 18.88mL |
| 5mM | 0.38mL | 1.89mL | 3.78mL |
| 10mM | 0.19mL | 0.94mL | 1.89mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
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