BiologicalActivity
HighaffinityC5areceptorantagonist(Ki=2.2nM).InhibitsC5a-inducedgenerationofreactivesuperoxidespecies,chemotaxisandintracellularCa2+mobilizationinhumanneutrophils(IC50valuesare1.6,2.7and3.1nM,respectively).
CompoundLibraries
W54011isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 493.08 |
| Formula | C30H36N2O2.HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 405098-33-1 |
| PubChemID | 5311121 |
| InChIKey | UKBJWRMNGCDKNL-UHFFFAOYSA-N |
| Smiles | CC(C)C1=CC=C(N(CC2=CC=C(N(C)C)C=C2)C(C3C(C=C(OC)C=C4)=C4CCC3)=O)C=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.65 | 50 | |
| ethanol | 4.93 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight493.08.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.03mL | 10.14mL | 20.28mL |
| 5mM | 0.41mL | 2.03mL | 4.06mL |
| 10mM | 0.2mL | 1.01mL | 2.03mL |
| 50mM | 0.04mL | 0.2mL | 0.41mL |
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