
Serum-SalivaCorrelation | NA |
Sensitivity | <0.37>0.37> |
SampleTestVolume | 20μL |
RecommendedCollectionVolume | 50μL* |
SpecialConsiderations | IL-1Beta may be FlowRateDependent (theeffectofflowrateinindividualswithhigherlevelsofIL-1ßhasnotbeendetermined).Itisthereforeadvisabletocollectdataonsalivaflowincasethecorrectionforflowrateshouldbenecessary,ortoallowforfuturetestingofarchivedsamplesforadditionalbioMarkersthatmaybesensitivetoflowrate. |
CollectionProtocol | DownloadPDF |
Interleukin-1β(IL-1β)isoneofafamilyofBIOLOGicallyactivesmallproteinmoleculesknownascytokines. Cytokinesareproducedbyanumberofdifferentcelltypes,including macrophages,monocytes,fibroblasts,and dendriticcells.(1,2,3) IL-1βisanexampleofapro-inflammatorycytokine,sinceitisinvolvedinthebody’sinflammatoryresponsetoacuteorchronicinfections,ortoconditionsthatcauseapersistentlow-gradeinflammatorystate,suchasobesity.(4,5) IL-1βisthereforefrequentlyusedasabio-markerofinflammation.(6,7)AstudywithnormalmouseparotidacinarcellshasshownthattheysynthesizeIL-1βandstoreitinsecretorygranules.TheIL-1βisreleasedfromthegranulesfollowingα-andβ-adrenergicstimulation.(8)RelationshipsbetweenIL-1βlevelsinbloodandsalivaarenotfullyunderstood.
- Giannobile,W.V.,Beikler,T.,Kinney,J.S.,etal.(2009). Salivaasadiagnostictoolforperiodontaldisease:Currentstateandfuturedirections. Periodontology2000,50,52-64.
- Pirhonen,J.,Sareneva,R.,Kurimoto,M.,etal.(1999). VirusinfectionactivatesIL-1βandIL-18productioninhumanmacrophagesbyacaspase-1-dependentpathway. JImmunol,162(12),7322-29.
- Park,D.R.,Thomsen,A.R.,Frevert,C.W.etal.(2003). Fas(CD95)inducesproinflammatorycytokineresponsesbyhumanmonocytesandmonocyte-derivedmacrophages. JImmunol,170(12),6209-16.
- Hernández-Rodríguez,J.,Segarra,M.,Vilardell,C.,etal.(2004). Tissueproductionofpro-inflammatorycytokines(IL-1β,TNFα,andIL-6)correlateswiththeintensityofthesystemicinflammatoryresponseandwithcorticosteroidrequirementsingiant-cellarteritis. Rheumatology(Oxf.),43(3),294-301.
- Southerland,J.H.,Taylor,G.W.,Moss,K.,etal.(2006). Commonalityinchronicinflammatorydiseases:Periodontitis,diabetes,andcoronaryarterydisease. Periodontology2000,40,130-43.
- Tzouvelekis,A.,Pneumatikos,I,Bouros,D.(2005). Serumbiomarkersinacuterespiratorydistresssyndromeanailingprognosticator. RespirRes,6,62.
- Miller,C.S.,KingC.P.,Langub,M.C.,etal.(2006). Salivarybiomarkersofexistingperiodontaldisease:Across-sectionalstudy. JAmDentAssoc,137(3),322-29.
- Tanda,N.,Ohyama,H.,Yamakawa,M.,etal.(1998).IL-1βandIL-6inmouseparotidacinarcells:Characterizationofsynthesis,storage,andrelease. AmJPhysiol,274(1Pt1),G147-56.
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(1)优级纯试剂 亦称保证试剂,为一级品,纯度高,杂质极少,主要用于精密分析和科学研究,常以GR表示。
(2)分析纯试剂 亦称分析试剂,为二级品,纯度略低于优级纯,杂质含量略高于优级纯,适用于重要分析和一般性研究工作,常以AR表示。
(3)化学纯试剂 为三级品,纯度较分析纯差,但高于实验试剂,适用于工厂、学校一般性的分析工作,常以CP表示。
(4)实验试剂 为四级品,纯度比化学纯差,但比工业品纯度高,主要用于一般化学实验,不能用于分析工作,常以 LR表示。
以上按试剂纯度的分类法已在我国通用。根据化学工业部颁布的“化学试剂包装及标志”的规定,化学试剂的不同等级分别用各种不同的颜色来标志,见表1。
表1 我国化学试剂的等级及标志
bhclna2so4nano3na2co3
chclnaohna2co3nacl
dba(oh)2nahco3alcl3nahso4
刚入这行,谢谢大家
A.H2SO4Na2SO4AgNO3BaCl2.
B.NaOHNa2CO3NaHSO4MgCl2
C.CaCl2NaNO3MgSO4BaCl2
D.HNO3KOHKClK2CO3


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