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Tocris/ABT 751/4138/10/10 mg
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Tocris/ABT 751/4138/10/10 mg
品牌 / 
Tocris
货号 / 
4138/10
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4000-520-616
Description:Inhibitorofmicrotubulepolymerization;antimitoticandantitumor
ChemicalName:N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Antimitoticagent,inhibitsmicrotubulepolymerization.Bindstoβ-tubulinonthecolchinesite;blockscellcycleatG2Mphaseandinducesapoptosis.Exhibitsantitumoractivity.Alsodisplaysactivityincelllinesresistanttovincristine,doxorubicinandcisplatin.Orallybioavailable.

CompoundLibraries

ABT751isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt371.41
FormulaC18H17N3O4S
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber141430-65-1
PubChemID3035714
InChIKeyURCVCIZFVQDVPM-UHFFFAOYSA-N
SmilesOC(C=C2)=CC=C2NC1=NC=CC=C1NS(C3=CC=C(OC)C=C3)(=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO37.14100
ethanol9.2925

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight371.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.69mL13.46mL26.92mL
5mM0.54mL2.69mL5.38mL
10mM0.27mL1.35mL2.69mL
50mM0.05mL0.27mL0.54mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet