BiologicalActivity
α5β1integrinreceptorantagonist.Reduceslivermetastasisandimprovessurvivalincombinationwith5-FU(Cat.No.3257)inamousemodelofcoloncancer.ReducesMLLtumorgrowthinratsanddecreasestumorvolumeofhumanMDA-MB-231cellxenograftsinmice.
TechnicalData
| M.Wt | 597.65 |
| Formula | C23H35N9O8S |
| Sequence | PHSCN (Modifications:Pro-1=N-terminalAc,Asn-5=C-terminalamide) |
| Storage | Storeat-20°C |
| CASNumber | 262438-43-7 |
| PubChemID | 9960285 |
| InChIKey | MMHDBUJXLOFTLC-WOYTXXSLSA-N |
| Smiles | CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(N)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto2mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight597.65.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.67mL | 8.37mL | 16.73mL |
| 5mM | 0.33mL | 1.67mL | 3.35mL |
| 10mM | 0.17mL | 0.84mL | 1.67mL |
| 50mM | 0.03mL | 0.17mL | 0.33mL |
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