BiologicalActivity
SelectiveHIF-1dimerizationinhibitor.Blocksprotein-proteininteractionofrecombinantHIF-1α,butnotHIF-2α,withHIF-1β(IC50=1.3μM).Inhibitshypoxia-inducedHIF-1activity,anddecreasesVEGFandCAIXexpressioninosteosarcomaandbreastcancercellsinvitro.AlsoreducestubularizationofhypoxicHUVECs.
TechnicalData
| M.Wt | 2559.1 |
| Formula | C111H188N42O24S2 |
| Sequence | CLLFVYCGRKKRRQRRRPPQ* (Modifications:Lactambridge:Cys-1toTyr-6),Disulfidebridge:1-1*) |
| Storage | Storeat-20°C |
| CASNumber | 1446322-66-2 |
| PubChemID | 72192490 |
| InChIKey | AWUUHEHYNQGEFC-XLZVTALKSA-N |
| Smiles | [H]N[C@@H](CSSC[C@@H]1N([H])C(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight2559.1.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.39mL | 1.95mL | 3.91mL |
| 5mM | 0.08mL | 0.39mL | 0.78mL |
| 10mM | 0.04mL | 0.2mL | 0.39mL |
| 50mM | 0.01mL | 0.04mL | 0.08mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
© 2005- 苏州蚂蚁淘生物科技有限公司 版权所有。
苏ICP备17049038号-11
苏公网安备 32059002001627号
声明：本网站部分产品受外界条件影响（包含但不限于进口国出口国政策限制等因素），无法提供销售服务，下单后，会由客服人员联系厂家确认后另行通知。部分危险品无法清关，请勿下单
我要提问
您的问题将推送给已购用户，TA们将会为你解答。