中国Tocris官网，Tocris Bioscience价格更新一级代理,Tocris/Chetomin/4705/1/1 mg,转录表达,克隆和表达,分子类,,Tocris Bioscience蚂蚁淘商城

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Tocris/Chetomin/4705/1/1 mg

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Tocris

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4705/1

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Description:BlocksinteractionofHIF-1α,HIF-2αandSTAT2withCBP/p300

ChemicalName:(3S,5aR,10bS,11aS)-2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-(3-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazABIcyclo[2.2.2]oct-1-yl)methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

TargetstheCH1domainofCBP/p300;inhibitsinteractionofHIF-1α,HIF-2αandSTAT2withCBP/p300.Attenuateshypoxia-inducedgeneexpressioninvitroandinvivo;rADIosensitizeshumanHT1080fibrosarcomacellsinvitro.

TechnicalData

M.Wt	710.87
Formula	C₃₁H₃₀N₆O₆S₄
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1403-36-7
PubChemID	90488965
InChIKey	ZRZWBWPDBOVIGQ-KIDIPURZSA-N
Smiles	CN(C([C@@](CO)7N(C)C3=O)=O)[C@]3(SS7)CC2=CN([C@@]5(C[C@@](SS9)6C8=O)C4=CC=CC=C4N[C@@]([H])5N6C([C@@](CO)9N8C)=O)C1=CC=CC=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

Solubility	SolubleinDMSO

Solubility

SolubleinDMSO

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight710.87.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.41mL	7.03mL	14.07mL
5mM	0.28mL	1.41mL	2.81mL
10mM	0.14mL	0.7mL	1.41mL
50mM	0.03mL	0.14mL	0.28mL

ProductDatasheets

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BiologicalActivity

TechnicalData

SolubilityData

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