Tocris试剂产品信息 Tocris配体,Tocris/Echinomycin/5520/1/1 mg,转录表达,克隆和表达,分子类,,Tocris Bioscience蚂蚁淘商城

商品信息

联系客服

郑重提醒：

无质量问题不接受退换货，下单前请仔细核对信息。

下单后请及时联系客服核对商品价格，订单生效后再付款。

Tocris/Echinomycin/5520/1/1 mg

品牌 /

Tocris

货号 /

5520/1

官网地址

美元价：

登录查看

(友情提示：该价格仅为参考，欢迎联系客服询价！)

数量：

免费咨询热线

4000-520-616

商品介绍售后保障相关文章商品咨询

联系客服

Description:HighlypotentandselectiveHIF-1αinhibitor

AlternativeNames:QuinomycinA

ChemicalName:N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic(37)-thioether

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HighlypotentandselectiveHIF-1αinhibitor(IC₅₀=29.4pM).SelectivelyinhibitsHIF-1bindingtotheVEGFpromoterwithoutaffectingthebindingofAP-1orNF-κB.Inhibitscolonyformationofcancerstemcells(CSC)witha100-foldselectivityovernormalhematopoieticProgenitorcells.ErADIcatesmouselymphomasandhumanAMLxenograftsbyeliminatingCSCs.

TechnicalData

M.Wt	1101.26
Formula	C₅₁H₆₄N₁₂O₁₂S₂
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	512-64-1
PubChemID	91826096
InChIKey	AUJXLBOHYWTPFV-LDUXBRJQSA-N
Smiles	O=C(N[C@](C(N[C@H](C(N(C)[C@@](C(SC[C@@](N(C)C([C@H](C)NC4=O)=O)([H])C3=O)SC)([H])C(N(C)[C@@H]([C@@H](C)C)C(OC[C@]([H])4NC(C5=CN=C(C=CC=C6)C6=N5)=O)=O)=O)=O)C)=O)([H])COC([C@H]([C@@H](C)C)N3C)=O)C2=NC1=CC=CC=C1N=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	5.51	5

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight1101.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	0.91mL	4.54mL	9.08mL
5mM	0.18mL	0.91mL	1.82mL
10mM	0.09mL	0.45mL	0.91mL
50mM	0.02mL	0.09mL	0.18mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

Selectanotherlanguage:

BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

MolarityCalculator

ReconstitutionCalculator

DilutionCalculator

ProductDatasheets