中国Tocris公司 Tocris Bioscience产品促销,Tocris/GN 44028/5655/10/10 mg,转录表达,克隆和表达,分子类,,Tocris Bioscience蚂蚁淘商城

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Tocris/GN 44028/5655/10/10 mg

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Tocris

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5655/10

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4000-520-616

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Description:PotentHIF-1αinhibitor

ChemicalName:N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentHIF-1αinhibitor(IC₅₀=14nM).Inhibitshypoxia-inducedHIF-1αtranscriptionalactivitywithoutsuppressingHIF-1αmRNAexpression,HIF-1αproteinaccumulation,orHIF-1α/HIF-1βheterodimerization.Cytotoxictoarangeofcancercelltypesinvitro.

TechnicalData

M.Wt	305.33
Formula	C₁₈N₁₅N₃O₂
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1421448-26-1
PubChemID	71625259
InChIKey	CGZKSZVSWAAUHE-UHFFFAOYSA-N
Smiles	C12=CC=CC=C1C3=C(C(NC4=CC(OCCO5)=C5C=C4)=NN3)C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	30.53	100
	ethanol	30.53	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight305.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.28mL	16.38mL	32.75mL
5mM	0.66mL	3.28mL	6.55mL
10mM	0.33mL	1.64mL	3.28mL
50mM	0.07mL	0.33mL	0.66mL

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