BiologicalActivity
E2Ftranscriptionfactorinhibitor;inhibitsE2FDNAbindingactivity.InhibitsE2F4DNAbindingandreducesE2F4proteinlevelsinA375melanomacells.InducesapoptosisofA375andMDA-MB-231breastcancercells.InhibitsA375proliferationandinvasioninathreedimensionalskinmodelofA375invasion.Alsoattenuateshumanembryonicstemcellproliferation.
TechnicalData
| M.Wt | 399.48 |
| Formula | C25H25N3O2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 353519-63-8 |
| PubChemID | 2895500 |
| InChIKey | CYNZBLNMIJNBSF-UHFFFAOYSA-N |
| Smiles | CC1=C(OCC)C=CC(C(C3=C(O)C(N=C(C)C=C4)=C4C=C3)NC2=NC=CC=C2)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.99 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight399.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.5mL | 12.52mL | 25.03mL |
| 5mM | 0.5mL | 2.5mL | 5.01mL |
| 10mM | 0.25mL | 1.25mL | 2.5mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
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