BiologicalActivity
InhibitorofHIF-1α.Thoughttoactviadown-regulationofHIF-1αproteinsynthesis;reducesphosphorylationofeIF4Ebindingprotein1(4EBP1)andp70S6Kinhypoxicconditions.Alsoblockshypoxia-inducedHIF-1αaccumulationinarangeofhumancancercelllines.InhibitstheexpressionofHIFtargetgenes,suchascarbonicanhydraseIXandMMP2.
TechnicalData
| M.Wt | 570.38 |
| Formula | C16H16Cl4N2O4S4 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 927822-86-4 |
| PubChemID | 16047442 |
| InChIKey | REQLACDIZMLXIC-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(Cl)C(S(NCCSSCCNS(C2=C(Cl)C=CC(Cl)=C2)(=O)=O)(=O)=O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 57.04 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight570.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.75mL | 8.77mL | 17.53mL |
| 5mM | 0.35mL | 1.75mL | 3.51mL |
| 10mM | 0.18mL | 0.88mL | 1.75mL |
| 50mM | 0.04mL | 0.18mL | 0.35mL |
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