BiologicalActivity
Cryptochromeprotein(CRY)stabilizer;blocksproteasome-mediateddegradationofCRY1andCRY2.LengthenscircadianperiodinmouseNIH-3T3fibroblastswithoutalteringcaseinkinaseactivity.Repressesglucagon-inducedhepaticgluconeogenesisthroughtheinductionofPck1andG6pcexpression.
CompoundLibraries
KL001isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 398.48 |
| Formula | C21H22N2O4S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 309928-48-1 |
| PubChemID | 2888648 |
| InChIKey | OQAFDLPAPSSOHY-UHFFFAOYSA-N |
| Smiles | OC(CN(CC4=CC=CO4)S(C)(=O)=O)CN2C1=CC=CC=C1C3=C2C=CC=C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.85 | 100 | |
| ethanol | 7.97 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight398.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.51mL | 12.55mL | 25.1mL |
| 5mM | 0.5mL | 2.51mL | 5.02mL |
| 10mM | 0.25mL | 1.25mL | 2.51mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
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