BiologicalActivity
Nrf2activator;interactswiththeNrf2-bindingsiteofKeap1.DownregulatestheexpressionoffibrogenicgenesandincreasesantioxidanteffectsinNASHratmodelsofliverdisease.
CompoundLibraries
NK252isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 285.26 |
| Formula | C13H11N5O3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1414963-82-8 |
| PubChemID | 71618700 |
| InChIKey | FNSCFQXZZNCDAI-UHFFFAOYSA-N |
| Smiles | O=C(NC2=NN=C(C3=CC=CO3)O2)NCC1=CC=CC=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 28.53 | 100 | |
| DMSO | 28.53 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight285.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.51mL | 17.53mL | 35.06mL |
| 5mM | 0.7mL | 3.51mL | 7.01mL |
| 10mM | 0.35mL | 1.75mL | 3.51mL |
| 50mM | 0.07mL | 0.35mL | 0.7mL |
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