BiologicalActivity
HighaffinityandselectiveHIF-2αinhibitor(Kd=81nM).BindstotheHIF-2αPAS-Bdomain;disruptsHIF-2α-ARNTheterodimerization.Exhibits>60-foldselectivityforHIF-2αoverHIF-1α.DecreasesHIF-2αDNA-bindingandattenuatesexpressionofHIF-2αtargetgenesinvitro.
CompoundLibraries
TC-S7009isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 308.65 |
| Formula | C12H6ClFN4O3 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 1422955-31-4 |
| PubChemID | 70697712 |
| InChIKey | CDQUJZKBRAFWNG-UHFFFAOYSA-N |
| Smiles | ClC1=CC(F)=CC(NC3=C([N+]([O-])=O)C2=NON=C2C=C3)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.86 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight308.65.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.24mL | 16.2mL | 32.4mL |
| 5mM | 0.65mL | 3.24mL | 6.48mL |
| 10mM | 0.32mL | 1.62mL | 3.24mL |
| 50mM | 0.06mL | 0.32mL | 0.65mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
© 2005- 苏州蚂蚁淘生物科技有限公司 版权所有。
苏ICP备17049038号-11
苏公网安备 32059002001627号
声明：本网站部分产品受外界条件影响（包含但不限于进口国出口国政策限制等因素），无法提供销售服务，下单后，会由客服人员联系厂家确认后另行通知。部分危险品无法清关，请勿下单
我要提问
您的问题将推送给已购用户，TA们将会为你解答。