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Description:AREactivator;inducesNrf2-ARE-dependenttranscription
ChemicalName:1-Chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-benzo[c]thiophen-4(5H)-one
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Antioxidantresponseelement(ARE)activator;disruptsNrf2/Keap1andKeap1/Cul3interactionsandstABIlizesNrf2.ActivatesAREinanNrf2andPI3-kinasedependentmanner.Inducescytoprotectivegeneexpressioninvitroandinvivo.
TechnicalData
| M.Wt | 292.8 |
| Formula | C11H13ClO3S2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 882288-28-0 |
| PubChemID | 2820824 |
| InChIKey | PVJWSALSWFDIMS-UHFFFAOYSA-N |
| Smiles | O=C1CC(C)(C)CC2=C(Cl)SC(S(=O)(C)=O)=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.28 | 100 | |
| ethanol | 14.64 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight292.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.42mL | 17.08mL | 34.15mL |
| 5mM | 0.68mL | 3.42mL | 6.83mL |
| 10mM | 0.34mL | 1.71mL | 3.42mL |
| 50mM | 0.07mL | 0.34mL | 0.68mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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