This monoclonal antibody is recommended for neutralization of human IL-12/-23 (p40) bioactivity. The antibody is specific for the p40 subunit of IL-12 and IL-23. See Additional information.

The monoclonal antibody is supplied in PBS without preservatives. Endotoxin content is below 10 EU/mg.

IL-12/-23 (p40)Interleukin-12 (IL-12, IL12) is, when biologically active, a heterodimer (p70) consisting of two covalently linked subunits, p35 and p40. IL-12 is produced by antigen-presenting cells, specifically dendritic cells and macrophages. IL-12 is a proinflammatory cytokine that promotes Th1-type responses by inducing IFN-γ production and enhancing proliferation and cytotoxicity of NK and T cells.Interleukin-23 (IL-23) is a disulfide-linked heterodimer which consists of a unique p19 subunit and the p40 subunit of IL-12. IL-23 is a proinflammatory cytokine, which is produced by macrophages and dendritic cells upon infections with certain pathogens. The IL-23 receptor is expressed on Th17 cells and IL-23 is responsible for Th17 expansion and stabilization.Since both IL-12 and IL-23 heterodimers comprise the p40 subunit, capture immunoassays based on antibodies to p40 will detect both cytokines. Such assays can also detect p40 monomers and dimers.

Orders to Mabtech can be placed online, by email, or by phone/fax to any of our offices.

Email:Send your order toorder@mabtech.com.

Upon request, Mabtech"s antibodies are available in unconjugated format and may be purchased in bulk. Please contact Mabtech directly for further details.