| BAY-X 1005Potent FLAP inhibitor |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
Nature.2018 Nov;563(7731):407-411.Nature.2018 Jun 13.Nature.2018 Jun 27.Nature.2018 Mar 29;555(7698):673-677.Nature.2017 Sep 7;549(7670):96-100.Nature.2016 Apr 21;532(7599):398-401.
Science.2016 Aug 5;353(6299)594-8Nat Nanotechnol.2017 Dec;12(12):1190-1198.Nature Biotechnology.2017 Jun;35(6):569-576Nat Med.2018 Sep 17.Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.Cell.Available online 25 October 2018.Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.Cell.2018 Jun 28;174(1):172-186.e21.Cell.2018 Feb 22;172(5):1007-1021.e17.Cell.2017 Nov 30;171(6):1284-1300.e21.Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.Cell.2017 Jul 13;170(2):312-323Nat Med.2018 Jan 29.Nat Med.2017 Nov;23(11):1342-1351.Cell.2017 Apr 6;169(2):286-300.Cell.2015 Aug 27;162(5):987-1002.Cell.2015 Feb 12;160(4):729-44.Nature Medicine.2017 Apr;23(4):493-500.Cancer Cell.2018 May 14;33(5):905-921.e5.Cancer Cell.2018 Apr 9;33(4):752-769.e8.Cancer Cell.2018 Mar 12;33(3):401-416.e8.Cancer Cell.2017 Aug 14;32(2):253-267.e5.Nat Methods.2018 Jul;15(7):523-526.Cell Stem Cell.2018 May 3;22(5):769-778.e4.Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.Quality Control & MSDS
- View current batch:
- Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
BAY-X 1005 Dilution Calculator
calculate
BAY-X 1005 Molarity Calculator
calculate
| Cas No. | 128253-31-6 | SDF | Download SDF |
| Chemical Name | (S)-2-cyclopentyl-2-(4-(quinolin-2-ylmethoxy)phenyl)acetic acid | ||
| Canonical SMILES | OC([C@H](C(C=C1)=CC=C1OCC2=NC3=CC=CC=C3C=C2)C4CCCC4)=O | ||
| Formula | C23H23NO3 | M.Wt | 361.43 |
| Solubility | <36.14mg l="" in="" dmso=""> | Storage | Store at RT |
| Physical Appearance | Beige solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
BAY-X 1005 is a selective inhibitor of 5-lipoxygenase-activating protein [1].
5-lipoxygenase-activating protein (FLAP) is an integral protein and plays an important role in the activation of 5-lipoxygenase (5-LOX) and the synthesis of leukotrienes, which regulating immune responses.
BAY-X 1005 is a selective inhibitor of leukotriene synthesis. BAY X 1005 binds to FLAP and inhibits 5-LOX translocation from the cytosol to membranes [1]. BAY-X1005 inhibited LTB4 synthesis with IC50 values of 0.22, 0.026 and 0.039 μM for isolated PMNL of human, rat and mouse respectively and inhibited LTC4 synthesis with IC50 value of 0.021 μM in mouse macrophages [2].
In the arachidonate-induced mouse ear inflammation test, BAY-X 1005 inhibited myeloperoxidase activity and edema formation with ED50 values of 7.9 and 48.7, respectively [2].
Also, BAY-X 1005 (100 mg/kg) reduced platelet-activating factor-induced death of mice by 51% in a dose-dependent way. In animal models, BAY-X 1005 inhibited the synthesis of LTB4 and LTC4, which reduced edema formation, the vascular phenomena of inflammation and leukocyte immigration [3].
References:[1]. Hatzelmann A, Fruchtmann R, Mohrs KH, et al. Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X 1005: implications for biological regulation of 5-lipoxygenase. Agents Actions, 1994, 43(1-2): 64-68.[2]. Müller-Peddinghaus R, Fruchtmann R, Ahr HJ, et al. BAY X1005, a new selective inhibitor of leukotriene synthesis: pharmacology and pharmacokinetics. J Lipid Mediat, 1993, 6(1-3): 245-248.[3]. Müller-Peddinghaus R, Kohlsdorfer C, Theisen-Popp P, et al. BAY X1005, a new inhibitor of leukotriene synthesis: in vivo inflammation pharmacology and pharmacokinetics. J Pharmacol Exp Ther, 1993, 267(1): 51-57.
ebiomall.com
>
>
>
>
>
>
>
>
>
>
>
>
尤其是获得SCI文献引用的产品，
绝对ok的
我想用酶联免疫斑点（ELISPOT）技术测定NK细胞活性，但不知道哪里能买到试剂盒，特向大家求助，谢谢。
