Overview:
GRK5isamemberoftheguaninenucleotide-bindingprotein(Gprotein)-coupledreceptorkinasesubfamilyoftheSer/Thrproteinkinasefamily(1).ItphosphorylatestheactivatedformsofGprotein-coupledreceptorsthusinitiatingtheirdeactivation.GRK5playsaroleinregulatingthemotilityofpolymorphonuclearleukocytes(PMNs).DesensitizationofGprotein-coupledreceptorsregulatesthenumberofpolymorphonuclearleukocytes(PMNs),aswellastheirmotilityandABIlitytostopuponcontactwithpathogensortargetcells,andthisdesensitizationismediatedbyGRK5(2).
GeneAliases:
GPRK5
GenbankNumber:
NM_005308
References:
1.Haribabu,B.etal:IdentificationofadditionalmembersofhumanG-protein-coupledreceptorkinasemultigenefamily.Proc.Nat.Acad.Sci.90:9398-9402,1993.2.Fan,J.etal:Toll-likereceptor-4(TLR4)signalingaugmentschemokine-inducedneutrophilmigrationbymodulatingcellsurfaceexpressionofchemokinereceptors.NatureMed.9:315-321,2003.
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没有序列识别的功能,他就是简单的催化相邻DNA链的5-P末端和3'-OH末端以磷酸二酯键结合的反应,需ATP作辅酶。 不仅可以催化粘性末端之间或平滑末端之间的DNA的连接,也催化DNA与RNA之间以及少数RNA之间的连接。
反转录酶(Reversetranscripatase)是以RNA为模板指导三磷酸脱氧核苷酸合成互补DNA(cDNA)的酶。哺乳类C型病毒的反转录酶和鼠类B型病毒的反转录酶都是一条多肽链。鸟类RNA病毒的反转录酶则由两上亚基结构。真核生物中也都分离出具有不同结构的反转录酶。
TERT是端粒酶逆转录酶
人的端粒酶是由端粒酶逆转录酶、端粒酶RNA和一种假尿嘧啶合成酶组成

