
Fpg(alsoknownasFormamidopyrimidineDNAglycosylase,MutM,FAPYDNAGlycosylase,and8-oxoguanineDNAglycosylase)participatesinthebase-excision(BER)pathwayofDNArepairenzymesandactsbothasaN-glycosylaseandanAP-lyase.TheN-glycosylaseactivityreleasesdamagedpurinesfromdoublestrandedDNA,generatinganapurinic/apyrimidinic(APsite).TheAP-lyaseactivitycleavesboththe3′and5′phosphodiesterbondsattheAPsite,producinga1basegapintheDNAand3′and5′phosphatetermini.BasesrecognizedandremovedbyFpginclude7,8-dihydro-8-oxoguanine(8-oxoguanine),8-oxoadenine,fapy-guanine,methy-fapy-guanine,fapy-adenine,aflatoxinB1-fapy-guanine,5-hydroxy-cytosineand5-hydroxy-uracil(1,2).
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