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Medchemexpress/Ciprofloxacin/HY-B0356/5g
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Medchemexpress/Ciprofloxacin/HY-B0356/5g
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MedChemExpress
货号 / 
HY-B0356-1g
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Ciprofloxacinisafluoroquinoloneantibiotic,exhibitingpotentantibacterialactivity.
Description

Ciprofloxacinisafluoroquinoloneantibiotic,exhibitingpotentantibacterialactivity.

InVitro

Ciprofloxacinisafluoroquinoloneantibiotic,exhibitingpotentantibacterialactivity[1].Ciprofloxacin(CIP)showspotentactivityagainstY.pestiswithMIC90of0.03μg/mL[2].

InVivo

Ciprofloxacin(1mg/L)inducesglutathione-S-transferase(GST)activity,incontrastwithinhibitedGSTandCatalase(CAT)oflarvaeexposedtoenrofloxacin.Ciprofloxacin(≥10μg/L)andenrofloxacinareecotoxicfordevelopment,growth,detoxifying,andoxidativestressenzymesinanuranamphibianlarvae[1].Inamurinemodelofpneumonicplague,Ciprofloxacin(30mg/kg,i.p.)resultsinadrugexposurewhichissimilartothedrugexposureobservedinhumanfollowinga500mgdoseoforalCiprofloxacin.IntraperitonealCiprofloxacinreducesthelungbacterialloadcomparetocontrolstreatedwithintraperitonealPBS[3].

ClinicalTrial
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References
  • [1].PeltzerPM,etal.Ecotoxicityofveterinaryenrofloxacinandciprofloxacinantibioticsonanuranamphibianlarvae.EnvironToxicolPharmacol.2017Feb4.pii:S1382-6689(17)30029-7.

    [2].SteenbergenJ,etal.InVitroandInVivoActivityofOmadacyclineAgainstTwoBiothreatPathogens:BacillusanthracisandYersiniapestis.AntimicrobAgentsChemother.2017Feb21.

    [3].HamblinKA,etal.InhaledLiposomalCiprofloxacinProtectsagainstaLethalInfectioninaMurineModelofPneumonicPlague.FrontMicrobiol.2017Feb6;8:91.

PreparingStockSolutions
ConcentrationVolumeMass1mg5mg10mg
1mM3.0180mL15.0902mL30.1805mL
5mM0.6036mL3.0180mL6.0361mL
10mM0.3018mL1.5090mL3.0180mL
Pleaserefertothesolubilityinformationtoselecttheappropriatesolvent.
CellAssay
[2]

Antibiotics(includingCiprofloxacin)areseriallydiluted2-foldin50μLofcation-adjustedMueller-Hintonbroth(CAMHB).Theantibiotic(includingCiprofloxacin)rangesare8to0.004μg/mLor64to0.03μg/mLbasedonafinalwellvolumeof100μLafterinoculation.

BacterialinoculaarepreparedbysUSPendingcoloniesintoMueller-Hintonbroth(CAMHB)(containingCiprofloxacin)from18to24h(B.anthracis)or42to48h(Y.pestis)onsheepbloodagar(SBA)platesthatareincubatedat35°C.SuspendedculturesaredilutedwithCAMHBtoabacterialcelldensityof105CFU/mLadjustedbasedontheopticaldensityat600nm.Toeachwellofthe96-wellplate,50μLofdilutionsisaddedforafinalinoculumof~5×104CFU/well.Platesareincubatedat35°C.MICsaredeterminedvisuallyat18to24h(B.anthracis)or42to48h(Y.pestis)andalsobyabsorbanceat600nm[2].MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly.

AnimalAdmiNISTration
[3]

FemaleBALB/cAnNCrl(BALB/c)mice,8to10weeksoldand20g(±4g)areusedinthisassay.AsingledoseofCiprofloxacin(30mg/kg)isadministeredtomice(n=30)viatheintraperitoneal(i.p.)route.Themice(n=3/timepoint/group)areculledat1,10,20,or30minand1,1.5,2,4,8,12hfollowingCiprofloxacinadministrationand1,15,or30minand1,2,4,6,10,18,or24hfollowingDRCFIorCFIadministration.Bloodsamplingpointsarechosenbasedupontheshorthalf-lifeofCiprofloxacinandlongerhalf-lifeofCFI.Bloodandlungs(wholeorgan)arecollectedpostmortemforanalysis.ThelungdosesfollowingCFIorDRCFIadministrationarecalculatedusingtheconcentrationofCiprofloxacininthelungsamplesat1minpost-administration[3].MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly.

References
  • [1].PeltzerPM,etal.Ecotoxicityofveterinaryenrofloxacinandciprofloxacinantibioticsonanuranamphibianlarvae.EnvironToxicolPharmacol.2017Feb4.pii:S1382-6689(17)30029-7.

    [2].SteenbergenJ,etal.InVitroandInVivoActivityofOmadacyclineAgainstTwoBiothreatPathogens:BacillusanthracisandYersiniapestis.AntimicrobAgentsChemother.2017Feb21.

    [3].HamblinKA,etal.InhaledLiposomalCiprofloxacinProtectsagainstaLethalInfectioninaMurineModelofPneumonicPlague.FrontMicrobiol.2017Feb6;8:91.

MolecularWeight

331.34

Formula

C₁₇H₁₈FN₃O₃

CASNo.

85721-33-1

Storage
Powder-20°C3years
 4°C2years
Insolvent-80°C6months
 -20°C1month
Shipping

RoomtemperatureincontinentalUS;mayvaryelsewhere

Solvent&Solubility

DMSO:<0.1=""mg/ml;=""acetic=""acid:=""≥=""165="">

*"<1 mg/ml"="" means="" slightly="" soluble="" or="" insoluble.="" "≥"="" means="" soluble,="" but="" saturation="">

Purity:99.55%