BiologicalActivity
InhibitorofSEROtoninandnoradrenalineuptake;alsoactivatesα2A-adrenoceptorsandantagonizes5-HT2receptors.Displaysantinociceptiveactivity.Tricyclicantidepressant(TCA).AlsoaTrkA/Bagonist.InducesneuriteoutgrowthinPC12cells.
TechnicalData
| M.Wt | 313.86 |
| Formula | C20H23N.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 549-18-8 |
| PubChemID | 11065 |
| InChIKey | KFYRPLNVJVHZGT-UHFFFAOYSA-N |
| Smiles | CN(CCC=C2/C3=C(C=CC=C3)CCC1=CC=CC=C12)C.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.39 | 100 | |
| ethanol | 31.39 | 100 | |
| water | 31.39 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight313.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.19mL | 15.93mL | 31.86mL |
| 5mM | 0.64mL | 3.19mL | 6.37mL |
| 10mM | 0.32mL | 1.59mL | 3.19mL |
| 50mM | 0.06mL | 0.32mL | 0.64mL |
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