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Description:PotentandselectiveNHE1inhibitor
ChemicalName:4-(1-Acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)benzamidehydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PotentandselectiveNHE1inhibitor(IC50=31nM).SelectiveforNHE1overNHE2andNHE3.Preventsischemicdamageinanischemiareperfusioninjuryisolatedratheartmodelexvivo.Preventsphenylephrine-inducedcardiomyocytehypertrophyinvitro,andattenuatescardiachypertrophyandleftventriculardysfunctionpostinfarctioninrats.Orallybioavailable.
TechnicalData
M.Wt | 392.8 |
Formula | C16H19F3N4O2.HCl |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
CASNumber | 1204329-34-9 |
PubChemID | 121513866 |
InChIKey | SLSZLEROFKLICF-UHFFFAOYSA-N |
Smiles | CC(N(CC2)CCC2C1=C(C(F)(F)F)C=C(C(NC(N)=N)=O)C=C1)=O.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 19.64 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight392.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.55mL | 12.73mL | 25.46mL |
5mM | 0.51mL | 2.55mL | 5.09mL |
10mM | 0.25mL | 1.27mL | 2.55mL |
50mM | 0.05mL | 0.25mL | 0.51mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
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ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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