Human CD152 (CTLA-4) is a cell surface glycoprotein expressed at low levels on activated T cells (1). CD152 is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2) and appears to function as a negative regulator of T cell activation (2, 3). A soluble fusion protein combining the extracellular (125aa) domain of human CD152 and murine IgG2a Fc (CTLA-4 Ig) was developed (4).
Molecular Structure: A soluble 110 kd dimeric fusion protein consisting of the extracellular (125aa) domain of human CTLA-4 fused to murine IgG2a Fc (233aa), with a predicted non glycosylated monomeric molecular weight of 40.1 kd.
Sequence:
CD152 mature EC: mhvaqpavvlassrgiasfvceyaspgkatevrvtvlrqadsqvtevcaatymtgneltflddsictgtssgnqvnltiqglramdtglyickvelmypppyylgigngtqiyvidpepcpdsdf
+linker: gt
fused to murine IgG2a Fc (233aa): eprgptikpcppckcpapnllggpsvfifppkikdvlmislspivtcvvvdvseddpdvqiswfvnnvevhtaqtqthredynstlrvvsalpiqhqdwmsgkefkckvnnkdlpapiertiskpkgsvrapqvyvlpppeeemtkkqvtltcmvtdfmpediyvewtnngktelnykntepvldsdgsyfmysklrvekknwvernsyscsvvheglhnhhttksfsrtpgk
Transfectant Cell Line: BHK
Functional Application: CD152 Ig binds with high affinity to human or mouse CD80 (B7-1) and CD86 (B7-2) (4, 5). CD152-muIg blocks the binding of anti-human CD80 (B7-1) and anti-humanCD86 (B7-2) mAbs to recepters on Raji cells. It cross reacts with CD80 and CD86 accross a broad range of mammalian species including pig (6, 7).
References:
1. T. Lindsten, et al, (1993) J Immunol 151: 3489-3499.
2. T.L. Walunas, et al, (1994) Immunity 1: 405-413.
3. N.J. Karandikar, et al, (1996) J Exp Med 184: 783-788.
4. A.H. Cross, et al, (1995) J Clin Invest 95: 2783-2789.
5. P.A. Morton, et al, (1996) J Immunol 156: 1047-1054.
6). Takamatsu H, RME Parkhouse, et al. (1999) Immunology 97(2):211-213.
7). Le Leduec JB, B Dubois, et al. (2016) Vaccine 34(7): 914-22. PMID: 26768129
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转运体是介导分子或离子转运跨过生物膜的物质。通常是蛋白质或酶。说得简单一点就是“运输工具”
受体是能与细胞外专一信号分子（配体）结合引起细胞反应的蛋白质。受体与配体结合即发生分子构象变化，从而引起细胞反应，如介导细胞间信号转导、细胞间黏合、细胞胞吞等细胞过程。它起的是“传达员” 的作用
感觉这样的提问是没有意义的
还是自己找下资料吧
1、被动转运（顺梯度转运）：药物依赖于膜两侧的浓度差，从高浓度的一侧向低浓度的一侧扩散转运的过程。大多数药物属于被动转运。
（1）特点：不需要载体，不消耗能量，无饱和现象和竞争性抑制。
（2）影扩散速度的因素：
①膜两侧的药物浓度差。
②药物的理化性质：分子量小、脂溶性大、极性小、非解离型的药物易通过生物膜转运，反之难跨膜转运。
2、主动转运：是一种逆浓度（或电位）差的转运。
特点：需要载体，消耗能量，有饱和现象和竞争性抑制。
