BiologicalActivity
Na+/Ca2+exhanger(NCX)inhibitor(IC50~100nM);TRPP3channelblocker(IC50=1.1μMforinhibitionofCa2+-activatedTRPP3channelactivity).Alsonon-selectiveDeg/ENaCfamilyblocker;reducesmechanosensitivityofcolonicafferents.Morepotentderivativeofamiloride(Cat.No.0890).
CompoundLibraries
BenzamilisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 356.21 |
| Formula | C13H14ClN7O.HCl |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 161804-20-2 |
| PubChemID | 5702295 |
| InChIKey | ZNWMRWWNJBXNKJ-UHFFFAOYSA-N |
| Smiles | NC1=C(Cl)N=C(C(NC(NCC2=CC=CC=C2)=N)=O)C(N)=N1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.62 | 100 | |
| water | 3.56 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight356.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.81mL | 14.04mL | 28.07mL |
| 5mM | 0.56mL | 2.81mL | 5.61mL |
| 10mM | 0.28mL | 1.4mL | 2.81mL |
| 50mM | 0.06mL | 0.28mL | 0.56mL |
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