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Description:MCTinhibitor;decreasesglycoloysis
ChemicalName:2-Cyano-3-(4-hydroxyphenyl)-2-propenoicacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Monocarboxylicacidtransport(MCT)inhibitor.Exhibitsantitumoralandantiangiogenicactivityingliomasinvivo;decreasesglycolyticmetabolism,migration,andinvasioninU251cells.Enhancestheeffectofantitumoragenttemozolomide(CatNo.2706).BlockslactateeffluxfromgliomacellsandsensitizescellstoirrADIation.
CompoundLibraries
CHCisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 189.17 |
Formula | C10H7NO3 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 28166-41-8 |
PubChemID | 5328791 |
InChIKey | AFVLVVWMAFSXCK-VMPITWQZSA-N |
Smiles | OC1=CC=C(/C=C(C#N)/C(O)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 18.92 | 100 | |
ethanol | 9.46 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight189.17.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 5.29mL | 26.43mL | 52.86mL |
5mM | 1.06mL | 5.29mL | 10.57mL |
10mM | 0.53mL | 2.64mL | 5.29mL |
50mM | 0.11mL | 0.53mL | 1.06mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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