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Tocris/CI 966 hydrochloride/1296/50/50 mg

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Tocris/CI 966 hydrochloride/1296/50/50 mg

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Tocris

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1296/50

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4000-520-616

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Description:SelectiveinhibitorofGAT-1

ChemicalName:1-[2-[bis[4-(Trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydropyridine-3-carboxylicacidhydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveinhibitoroftheGABAtransporterGAT-1(IC₅₀valuesare0.26and1.2μMatclonedhumanandratGAT-1respectively).Displaysover200-foldselectivityoverGAT-2andGAT-3.CentrallyactiveuponsystemicadmiNISTrationinvivo.Anticonvulsiveandneuroprotective.

CompoundLibraries

CI966hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	509.87
Formula	C₂₃H₂₁F₆NO₃.HCl
Storage	DesiccateatRT
Purity	≥98%(HPLC)
CASNumber	110283-66-4
PubChemID	198692
InChIKey	NUQWSOWKRTZJTO-UHFFFAOYSA-N
Smiles	Cl.OC(=O)C1=CCCN(CCOC(C2=CC=C(C=C2)C(F)(F)F)C2=CC=C(C=C2)C(F)(F)F)C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

Solubility	Solubleto10mMinethanolandto100mMinDMSO

Solubility

Solubleto10mMinethanolandto100mMinDMSO

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight509.87.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.96mL	9.81mL	19.61mL
5mM	0.39mL	1.96mL	3.92mL
10mM	0.2mL	0.98mL	1.96mL
50mM	0.04mL	0.2mL	0.39mL

ProductDatasheets

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