BiologicalActivity
EAAT2(GLT1)-selectivenon-transportableinhibitorofL-glutamateandL-aspartateuptake(Ki=23μM).130-foldselectiveoverEAAT1andEAAT3(Ki>3mM).AlsoavailableaspartoftheExcitatoryAminoAcidTransporterInhibitorTocriset™.
TechnicalData
| M.Wt | 215.25 |
| Formula | C10H17NO4 |
| Storage | StoreatRT |
| CASNumber | 52497-36-6 |
| PubChemID | 107883 |
| InChIKey | JQPDCKOQOOQUSC-OOZYFLPDSA-N |
| Smiles | O=C(C[C@H]1[C@@H]([C@H](C)C)CN[C@@H]1[C@](O)=O)O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| phosphatebufferedsaline | 21.52 | 100 | |
| 1eq.NaOH | 21.52 | 100 | |
| water | 5.38 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight215.25.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.65mL | 23.23mL | 46.46mL |
| 5mM | 0.93mL | 4.65mL | 9.29mL |
| 10mM | 0.46mL | 2.32mL | 4.65mL |
| 50mM | 0.09mL | 0.46mL | 0.93mL |
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