BiologicalActivity
Coronaryvasodilator;adenosinetransportinhibitor.Phosphodiesteraseinhibitor(IC50valuesare0.37,0.38,0.45,0.9and4.5μM forPDE11,6,10,5and8respectively).InhibitsENT1andENT2(IC50=144.8nMandKi=8.18nMforENT1).
CompoundLibraries
DipyridamoleisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 504.63 |
| Formula | C24H40N8O4 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 58-32-2 |
| PubChemID | 3108 |
| InChIKey | IZEKFCXSFNUWAM-UHFFFAOYSA-N |
| Smiles | OCCN(CCO)C1=NC(N2CCCCC2)=C2N=C(N=C(N3CCCCC3)C2=N1)N(CCO)CCO |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto100mMinDMSOandto10mMinethanol |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight504.63.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.98mL | 9.91mL | 19.82mL |
| 5mM | 0.4mL | 1.98mL | 3.96mL |
| 10mM | 0.2mL | 0.99mL | 1.98mL |
| 50mM | 0.04mL | 0.2mL | 0.4mL |
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