BiologicalActivity
Highaffinity,competitive5-HTandnoradrenaline(NA)re-uptakeinhibitor(Kivaluesare8.5and45nMfor5-HTandNAreuptakerespectivelyincorticalsynaptosomes;IC50valuesare28and46nMfor5-HTandNAreuptakerespectivelyinrathippocampalslices).Alsoblocksdopaminereuptake(Ki=300nMinstriatalsynaptosomes).Exhibitsantidepressantandanxiolyticeffects.Orallybioavailable.
CompoundLibraries
(S)-DuloxetinehydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 333.88 |
| Formula | C18H19NOS.HCl |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 136434-34-9 |
| PubChemID | 60834 |
| InChIKey | BFFSMCNJSOPUAY-LMOVPXPDSA-N |
| Smiles | CNCC[C@@H](C3=CC=CS3)OC2=CC=CC1=CC=CC=C12.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.39 | 100 | |
| water | 3.34 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight333.88.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3mL | 14.98mL | 29.95mL |
| 5mM | 0.6mL | 3mL | 5.99mL |
| 10mM | 0.3mL | 1.5mL | 3mL |
| 50mM | 0.06mL | 0.3mL | 0.6mL |
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