BiologicalActivity
Potent,non-competitiveexcitatoryaminoacidtransporter(EAAT)blocker.Preferentiallyinhibitsglutamate-induced[3H]D-aspartaterelease(IC50=1.6μM)ratherthan[3H]L-glutamateuptake(IC50=18μM).Moderatelyselective;displaysnoaffinityforNMDAandmetabotropicglutamatereceptors,andlowaffinityforAMPAandkainatereceptors(IC50valuesare43and8μMrespectively). .
TechnicalData
| M.Wt | 172.14 |
| Formula | C6H8N2O4 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 227619-64-9 |
| PubChemID | 90488747 |
| InChIKey | SKTBUVYVLORGED-ACIRMZHZSA-N |
| Smiles | OC1=NO[C@@]2([H])[C@@]([H])1[C@H]([C@@](O)=O)NC2.OC3=NO[C@]4([H])[C@]([H])3[C@@H](C(O)=O)NC4 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 1.72 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight172.14.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 5.81mL | 29.05mL | 58.09mL |
| 5mM | 1.16mL | 5.81mL | 11.62mL |
| 10mM | 0.58mL | 2.9mL | 5.81mL |
| 50mM | 0.12mL | 0.58mL | 1.16mL |
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