BiologicalActivity
IncreasesexpressionofglutamatetransporterEAAT2inPA-EAAT2cells.Displaysneuroprotectiveactivityinvivo.Showntoimprovelearningandmemory,restoresynapticintegrityandreduceamyloidplaqueburdeninAPPSw/Indmice.
TechnicalData
| M.Wt | 293.39 |
| Formula | C17H15N3S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 894002-50-7 |
| PubChemID | 7207425 |
| InChIKey | DUUQLWDHNYFUPP-UHFFFAOYSA-N |
| Smiles | CC1=CC=CC=C1CSC(N=N3)=CC=C3C2=NC=CC=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.34 | 100 | |
| ethanol | 5.87 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight293.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.41mL | 17.04mL | 34.08mL |
| 5mM | 0.68mL | 3.41mL | 6.82mL |
| 10mM | 0.34mL | 1.7mL | 3.41mL |
| 50mM | 0.07mL | 0.34mL | 0.68mL |
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